There is a strong and unsettling S&M feel throughout the film.

A graphic rape scene is shown.

A naked man violently disembowels another naked woman on bed.

Some extremely graphic gory violence

Some language. Not too much.

A drug is a key element of this film.

Despite being low budgeted, the film's atmosphere, sounds and visual imagery can be extremely hard for most viewers.

The beginning scene involves showing lab animals. None are shown to be actively harmed, but this can be upsetting for some viewers. Aside from tanks, none are shown again.