There's a lot of fully naked women throughout movie.

Some nude women are seen.

Many sexual references throughout.

A car blows up with Cheech and Chong in it after being covered in gasoline while Chong tries to light a joint. They are later covered in soot.

Strong language throughout.

Red has a very foul mouth and almost everything he says he swears in the sentence.

Cheech and Chong are stoners.

Other people are seen smoking and drinking.

In the end, Cheech and Chong do "space coke".