Characters are frequently in bed after sex or just before.

The innuendo in the series is usually silly and not passionate or sincere.

Very frequent sexual talk. No sex scenes though.

In the pilot the very first scene of the whole show takes place in a sperm bank.

In season 3 episode 21 A girl in bra and mini skirt with cleavage show.

Mild sexual innuendo (hints about sex acts, people in their underwear or in bed together).

Leonard slaps Sheldon mildly.

Infrequent and mild comical violence. All violence is used for comedic effect.

Use of "bitch" and "Ass" in most episodes "dick" in one episode said by Bernadette.

Uses of Bitch, Ass, Asshole and Bastard.

"Suck," "god," "crap," "piss," "hell," "damn," "ass," "bitch," "bastard," "balls," whore," "slut," and "asshole" respectively.

During the series, alcohol is used and mentioned a lot.

On rare occasion, smoking cigarettes.

There are references to drugs. These mostly relate to the pharmaceutical sales industry.

In the Season 8, episode 1, the use of cocaine by the fictional character Sherlock Holmes is mentioned.