There is frequent strong comic nudity and sex scenes, including female breasts and buttocks and on rare occasion male genitalia. There are also some explicit/vivid sound effects of body parts slapping against one another. These scenes are portrayed in an over-the-top rather than erotic fashion.

One human character has a sexual interest in Ebichu, which is a hamster. He fantasizes about her while having sex with his girlfriend. This is played for laughs, but may disturb some viewers.

Strong sexual references throughout, including references to orgasms, ejaculation, various sexual positions, etc.

An owner constantly punishes her pet hamster in bloody results for doing something 'wrong'.

Regular use of profanity, including a running gag about the word 'manko' (which translates to 'pussy'/'c**t' in English), one of the few truly vulgar words in the Japanese language.

Adults are seen casually drinking and smoking, and occasionally getting drunk. Intoxication occasionally plays a role in the storyline, such as a male flirting with another woman when they're drunk in front of his girlfriend.

There is some smoking.